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Performance Collagen SUPPLEMENT FACTS

Performance Collagen™

Fortigel hydrolyzed collagen is a novel ingredient aimed at joint cartilage regeneration, backed by clinical evidence for reducing pain, enhancing mobility, and promoting long-term cartilage health safely.
Collagen’s significance extends to skin elasticity and hydration; potentially enhancing skin moisture, elasticity, and reduce wrinkles for a more youthful appearance.

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Cellular Pathways

A positive effect of collagen peptides on the regeneration of hyaline cartilage was observed in cultured chondrocytes.
The stimulation of the extracellular matrix (ECM) synthesis is probably caused by specific Hyp-Pro-Gly containing peptides with a molecular size <10 kD.
Stimulate the growth and activity of fibroblasts, the cells responsible for producing collagen in the skin and other connective tissues.
Hyp-Pro-Gly peptides

Why this matters:

As individuals age, collagen levels decrease, leading to less flexible and more brittle cartilage. Agingrelated changes increase collagen cross-linking, stiffening cartilage and making it prone to fatigue failure. Structural collagen changes, including degradation, are associated with skin wrinkling, bone deterioration, and cardiovascular and respiratory issues. Cartilage degeneration, a result of aging, can lead to arthritis, also known as degenerative joint disease.

Clinical Studies

Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides.
  • 5g supplementation of FORTIGEL treatment was shown to decrease knee pain and stiffness and increase physical function after 6 weeks
  • After 12 weeks 40% of patients reported no knee pain and 70% achieved a positive effect of therapy
Clinical Studies

Synergy with Pentosan Polysulfate, BPC-157, GHK-Cu

Performance Collagen™ + Pentosan Polysulfate
Hydrolyzed Collagen is a key component in proteoglycans and collagen type II formation which can help repair cartilage degradation and decrease joint pain, typically used in joint and inflammatory pain protocols.
Collagen supplementation when broken down can form foundational building blocks for muscle and ligament repair. Sermorelin improves growth hormone secretion while BPC-157 has been shown to upregulate growth hormone receptors. These have been used in synergy to improve injury and recovery.
Collagen supplementation helps rejuvenate collagen type III in the skin which is important for skin elasticity and overall skin health. GHK-Cu has been shown to enhance skin elasticity.
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References

  1. Zdzieblik D, Oesser S, Gollhofer A, König D. Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides. Appl Physiol Nutr Metab. 2017 Jun;42(6):588-595. doi: 10.1139/apnm-2016-0390. Epub 2017 Jan 24. Erratum in: Appl Physiol Nutr Metab. 2017 Nov;42(11):1237. PMID: 28177710.

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