LeuSynergy™
Description
Ingredients
• Leucine 1.1 grams
• Resveratrol 50mg
• Pyroxdine 15mg
Recommended Use
Take 2 tablets in the morning and 2 tablets 90 minutes after lunch.
Down Stream Effects of SIRT-1 Activation
+ Leucine activates SIRT-1 by changing the amount of NAD+ needed
+ Low doses of Leucine between 1.0 and 1.5 grams were able to activate SIRT-1 without concom
Synergy with Leucine and SIRT-1/AMPK Activators to Modulate Nutrient Sensing
Leucine 1.1g/Pyridoxine 15mg BID vs Placebo
24-week Placebo Controlled Trial
+ Loss of waist circumference vs placebo at 4 weeks
+ 82% more weight loss vs placebo at 12 weeks
+ 2x the fat tissue loss vs placebo
Leucine 1.1g/Resveratrol 50mg BID vs Placebo
Pre-Diabetics Subjects Randomize
+ Improved insulin and glucose levels 60 minutes post-oral glucose tolerance test
+ Improved insulin and glucose dynamic
+ improved insulin resistance
References:
1. Zemel MB. Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span. J Med Food. 2020 Nov;23(11):1129-1135. doi: 10.1089/jmf.2020.0105. Epub 2020 Aug 4. PMID: 32758058.
2. Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest. 2013;123(7):2764-2772. doi:10.1172/JCI67227
3. Lan F, Weikel KA, Cacicedo JM, Ido Y. Resveratrol-Induced AMP-Activated Protein Kinase Activation Is Cell-Type Dependent: Lessons from Basic Research for Clinical Application. Nutrients. 2017 Jul 14;9(7):751. doi:10.3390/nu9070751. PMID: 28708087; PMCID: PMC5537865.
4. Kitada M, Ogura Y, Monno I, Koya D. Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function. Front Endocrinol (Lausanne). 2019;10:187. Published 2019 Mar 27. doi:10.3389/fen-do.2019.00187
5. Iside C, Scafuro M, Nebbioso A, Altucci L. SIRT1 Activation by Natural Phytochemicals: An Overview. Front Pharmacol. 2020;11:1225. Published 2020 Aug 7. doi:10.3389/fphar.2020.01225
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