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LeuSynergy™

LeuSynergy™

An exercise and caloric restriction mimetic that works on NAD+ efficiency and sirt1 activation. This low-dose leucine compound is best known for its incredible enhancement of weight loss with GLP 1’s like semaglutide.
LeuSynergy + GLP-1s has become a foundational protocol for weight loss and metabolism optimization.

Details

Per Bottle 120 capsules
Serving Size 2
Directions 2 capsules in the morning and 2 capsules 90 minutes after lunch.

Supplement Facts

Amount per serving
L-Leucine 1100mg t
Vitamin B6 (as Pyridoxal 5 Phosphate) 15mg t
Resveratrol (from Polygonum Cuspidatum Extract) (NLT 98% Resveratrol) 50mg t
† Daily Value (DV) not established

Cellular Pathways

Delivering the right dose of Leucine decreases the amount of NAD needed to activate SIRT-1.

Celluar Pathways

Leucine at a concentration of 0.5mM was shown to decrease the kM of NAD by 50%.

With Leucine, LESS NAD+ is needed for SIRT-1 functions, improving NAD+ utilization in other cellular pathways.

Why this matters:

SIRT-1 Downstream Effects

Stimulates caloric restriction and exercise pathways through these gene transcription factors:

  • PGC-1a – The core regulator of mitochondrial biogenesis
  • PPAR – Regulate fat oxidation
  • AMPK – Master regulator of cell energy
  • NF-kB – Inhibition leads to decreased inflammation and oxidative stress

Clinical Studies

Human Pre-diabetic Subjects Randomized: Leucine-Resveratrol Synergy

  • Leucine 1.1 g + Resveratrol 50mg Twice Daily vs. Placebo

  • OGTT and 60 min glucose and insulin concentration

  • Reduced insulin resistance by 33%

  • Significant improvement and insulin/glucose dynamics

  • * Lipps J, Hagan S, Clark M, Davis D, Stone L, Survant L, et al.: Resveratrol synergy in pre-diabetes. Diabetes 2013;62: Poster 78-LB

Weight Loss – Fat Oxidation – Insulin Sensitivity

Weight Loss Chart

Synergy with GLP-1s

Semaglutide, Tirzepatide, Liraglutide – Studies show 15% reduction in body weight when semaglutide was accompanied by caloric restriction and exercise. Using an exercise mimetic like LeuSynergy is foundational in weight loss and metabolic health outcomes.

GLP-1: Increase in GLUT4 expression by activating AMPK

SIRT-1: Increase in GLUT4 expression through SIRT1 deacetylation of PGC-1a

References:

  1. Zemel MB. Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span. J Med Food. 2020 Nov;23(11):1129-1135. doi: 10.1089/jmf.2020.0105. Epub 2020 Aug 4. PMID: 32758058.
  2. Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest. 2013;123(7):2764-2772. doi:10.1172/JCI67227
  3. Lan F, Weikel KA, Cacicedo JM, Ido Y. Resveratrol-Induced AMP-Activated Protein Kinase Activation Is Cell-Type Dependent: Lessons from Basic Research for Clinical Application. Nutrients. 2017 Jul 14;9(7):751. doi:10.3390/nu9070751. PMID: 28708087; PMCID: PMC5537865.
  4. Kitada M, Ogura Y, Monno I, Koya D. Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function. Front Endocrinol (Lausanne). 2019;10:187. Published 2019 Mar 27. doi:10.3389/fen-do.2019.00187
  5. Iside C, Scafuro M, Nebbioso A, Altucci L. SIRT1 Activation by Natural Phytochemicals: An Overview. Front Pharmacol. 2020;11:1225. Published 2020 Aug 7. doi:10.3389/fphar.2020.012
LeuSynergy™

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