Butyrate prodrug, tributyrin, is proven to overcome the pharmacokinetic drawbacks of butyrate supplementation. Butyrate can epigenetically regulate gene expression. nuButyrate has the only regulatory compliant tributyrin on the market clinically substantiated to be bioavailable in the colon and to show improvement in boosting butyrate-producing bacteria. Butyrate has been shown to neutralize reactive oxygen species by the overexpression of glutathione peroxidase, causing the inhibition of NF-kB, leading to the activation of antioxidant enzymes and impairing inflammatory genes. nuButyrate is crucial to immune, gut, and metabolic health.