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GUTTIDES™

“Guttides” are a blend of gastrointestinal-focused peptides, specifically BPC-157 and KPV, recognized for their unique benefits in promoting gut health through anti-inflammatory actions and protective effects.
This combination targets gastrointestinal inflammation, crucial for maintaining gut function and influencing other health areas such as skin condition, weight management, and immune regulation. By addressing gut inflammation, these peptides support overall health and wellness.

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Cellular Pathways - BPC-157

  • Increases fibroblast migration and dispersal
  • Induces F-actin formation in fibroblasts
  • Enhances vascular expression of VEGFR2

Cellular Pathways - KPV

  • Inhibiting the activation of NF-kappaB
  • Inhibtis MAP kinase inflammatory pathways
  • Decreases proinflammatory cytokine secretion of TNF-A.

Why this matters:

When these two peptides are used in combination, they offer a comprehensive treatment strategy targeting multiple aspects of gut health. BPC-157 provides broad healing effects throughout the gastrointestinal system while KPV focuses on reducing inflammation specifically within the colon. This synergistic effect can lead to improved outcomes in patients with various gastrointestinal issues, enhancing nutrient uptake, reducing symptoms of disorders such as IBS, and generally promoting a healthier gut environment.

Clinical Studies

Stable Gastric Pentadecapeptide BPC-157 May Recover Brain–Gut Axis and Gut–Brain Axis Function

The cytoprotective stable gastric pentadecapeptide BPC 157, by its effects, might combine the brain–gut and gut–brain axis’ function in a particular way using its particular capabilities: modulation of angiogenesis, wound healing, and neuroprotection.

The cytoprotective stable gastric pentadecapeptide BPC 157, by its effects, might combine the brain–gut and gut–brain axis’ function in a particular way using its particular capabilities: modulation of angiogenesis, wound healing, and neuroprotection.

Synergy with GLP-1, Aesthetics Protocols, Larazotide

Guttides™ + GLP-1
Gastrointestinal inflammation creates a poor environment for metabolism inhibiting weightloss. Combining metabolic enhancement with GLP-1 while working on calming the inflammatory state with Guttides™ is a strategy for resistance to weight loss.
Gut health significantly affects the condition of the skin. Guttides™ have been used as part of pre and post in-office procedures to enhance aesthetic outcomes.
The protective effects of Guttides™ have been used with zonulin inhibiting peptides like larazotide to protect the gut from food intolerance and immune dysregulation.
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References

  1. Madzarac Goran, Vlainic Josipa, Rokotov Stancic Dinko, Filipcic Igor, Bencic Lovric Martina, Krstonijevic Zoran, Starcevic Neven, Baric Marko, Sucic Mario, Rukavina Iva, Sikiric Predrag, Crvenkovic Dalibor, Zukanovic Goran, Strbe Sanja, Grgic Tihomir, Drmic Domagoj, Vuletic Batelja Lovorka, Kolenc Danijela, Rucman Rudolf and Seiwerth Sven, Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications, Current Neuropharmacology 2016; 14 (8) . https://dx.doi.org/10.2174/1570159X13666160502153022
  2. Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). 2011 Mar;110(3):774-80. doi: 10.1152/japplphysiol.00945.2010. Epub 2010 Oct 28. PMID: 21030672.
  3. Chung-Hsun Chang,Wen-Chung Tsai,Miao-Sui Lin,Ya-Hui Hsu, andJong-Hwei Su Pang 01 MAR 2011https://doi.org/10.1152/japplphysiol.00945.2010
  4. Xiao B, Xu Z, Viennois E, Zhang Y, Zhang Z, Zhang M, Han MK, Kang Y, Merlin D. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. Mol Ther. 2017 Jul 5;25(7):1628-1640. doi: 10.1016/j.ymthe.2016.11.020. Epub 2017 Jan 28. PMID: 28143741; PMCID: PMC5498804

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These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure or prevent any disease. The information on this site is for educational purposes only and should not be considered medical advice. Please speak with an appropriate healthcare professional when evaluating any wellness-related therapy.

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