BPC-157

BPC-157, a peptide that is renowned for its healing properties, particularly in accelerating the repair of tendons, muscles, nerves, and ligaments. It exhibits anti-inflammatory effects that help reduce swelling and pain, aiding in quicker and more comfortable recovery.
Additionally, its potential neuroprotective and gut health benefits contribute indirectly to overall well-being and recovery processes.

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Cellular Pathways

BPC-157

Increases fibroblast migration and dispersal
Induces F-actin formation in fibroblasts
Enhances vascular expression of VEGFR2.
NO pathway and FAK pathway for vascular response due to injury

Why this matters:

When injuries occur or repair is needed, decreasing inflammation and formation of new blood vessels is required to help the tissue heal. BPC-157 is multi-faceted in helping healing tissues and decreasing recovery times.

Clinical Studies

The promoting effect of pentadecapeptide BPC-157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.

The activation of migration and spreading can be strengthened by the observation of increased F-actin formation in tendon fibroblasts after BPC-157 treatment. BPC-157 was further proven in the present study to be capable of activating the phosphorylation levels of FAK and paxillin in tendon fibroblasts.

Synergy with GLP-1, Sermorelin

BPC-157 + PPS for inflammation and pain

BPC-157 exerts anti-inflammatory effects by suppressing pro-inflammatory cytokines and promoting tissue repair, while PPS modulates glycosaminoglycan synthesis and stabilizes the extracellular matrix. Together, they enhance tissue regeneration, inhibit inflammatory signaling pathways, and modulate pain transmission, offering a comprehensive approach to alleviate inflammation and pain.

BPC-157 + Sermorelin for Injury recovery and prevention

Sermorelin’s optimization of growth hormone secretion facilitates tissue repair, while BPC-157’s enhancement of growth hormone receptor density synergistically complements this effect, potentially improving tissue healing and regeneration.

References

Hsieh MJ, Liu HT, Wang CN, Huang HY, Lin Y, Ko YS, Wang JS, Chang VH, Pang JS. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. J Mol Med (Berl). 2017 Mar;95(3):323-333. doi: 10.1007/s00109-016-1488-y. Epub 2016 Nov 15. PMID: 27847966.
Sikiric, Predrag & Seiwerth, Sven & Rucman, R. & Turkovic, B. & Rokotov, D.S. & Brcic, Luka & Sever, M. & Kliček, Robert & Radic, Bozo & Drmic, D. & Ilic, S. & Kolenc, Danijela & Suran, Jelena & Vrcic, Hrvoje & Sebecic, B.. (2012). Effect of Pentadecapeptide BPC 157 on Gastrointestinal Tract. Frontiers of Gastrointestinal Research. 30. 191-201. 10.1159/000338435.
Vukojevic J, Milavić M, Perović D, Ilić S, Čilić AZ, Đuran N, Štrbe S, Zoričić Z, Filipčić I, Brečić P, Seiverth S, Sikirić P. Pentadecapeptide BPC 157 and the central nervous system. Neural Regen Res. 2022 Mar;17(3):482-487. doi: 10.4103/1673-5374.320969. PMID: 34380875; PMCID: PMC8504390.
Krivic A, Anic T, Seiwerth S, Huljev D, Sikiric P. Achilles detachment in rat and stable gastric pentadecapeptide BPC 157: Promoted tendon-to-bone healing and opposed corticosteroid aggravation. J Orthop Res. 2006 May;24(5):982-9. doi: 10.1002/jor.20096. PMID: 16583442.
The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration Chung-Hsun Chang, Wen-Chung Tsai, Miao-Sui Lin, Ya-Hui Hsu, and Jong-Hwei Su Pang Journal of Applied Physiology 2011 110:3, 774-780

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BPC-157

Cellular Pathways

Why this matters:

Clinical Studies

Synergy with GLP-1, Sermorelin

References

a longevity science and wellness education network

8144 Okeechobee Blvd Unit A 
West Palm Beach, FL 33411

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Our Story

BPC-157

Cellular Pathways

Why this matters:

Clinical Studies

Synergy with GLP-1, Sermorelin

References

a longevity science and wellness education network

8144 Okeechobee Blvd Unit A West Palm Beach, FL 33411

Formulations

Providers

Learning

Support

Our Story

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8144 Okeechobee Blvd Unit A 
West Palm Beach, FL 33411