Great question. It’s not that high-dose leucine is harmful—it simply activates different pathways. Doses above ~2.5 grams primarily stimulate mTOR, promoting anabolic signaling and muscle protein synthesis. This can still be beneficial, especially in physically active or aging populations aiming to preserve or build muscle.
The mitochondrial and metabolic benefits discussed in the module—linked to AMPK and SIRT1 activation—occur at lower doses (around 1.5 grams or less) and in the absence of food, mimicking caloric restriction or exercise.
With iCell Water, although the total leucine content is 3 grams per serving, it’s consumed gradually over time, not all at once. Unless a patient drinks the full 2 liters within a short window, the actual absorbed dose per hour remains in the lower range, making it compatible with LeuSynergy and not likely to blunt the mitochondrial signaling pathways.
So in practice, combining iCell Water with LeuSynergy doesn’t result in excessive leucine exposure, especially when spread throughout the day.
