Yes, there are several human studies investigating leucine as an exercise mimetic, particularly when combined with other compounds:
Leucine + Resveratrol:
A study reported positive outcomes when combining leucine with low-dose resveratrol, showing improvements in metabolic markers and mitochondrial function in humans.
Study link ➝ https://www.liebertpub.com/doi/abs/10.1089/jmf.2020.0105?journalCode=jmf
Leucine + Pyridoxine:
This combination demonstrated enhanced fat loss in humans by targeting metabolic flexibility and adipocyte function.
Study link ➝ https://pmc.ncbi.nlm.nih.gov/articles/PMC3755702/
Leucine + Metformin + Sildenafil:
A randomized controlled trial explored the synergistic activation of AMPK and SIRT1 pathways. The combination significantly reduced triglyceride levels and improved HbA1c in obese individuals.
Study link ➝ https://pmc.ncbi.nlm.nih.gov/articles/PMC9035320/
