DHH-B

Name: DHH-B
SKU: 300526235
Price: 149 USD
Availability: InStock

Dihydrohonokiol (DHH-B) is a natural compound extracted from magnolia bark, known for its anxiolytic effects. It promotes a sense of calm without causing motor dysfunction, amnesia, or physical dependence. Unlike synthetic drugs, DHH-B doesn’t exacerbate side effects or lead to withdrawal symptoms.
As a potent form of honokiol, it offers a natural alternative for anxiety and stress management.

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Cellular Pathways

Chronic administration of honokiol, a natural compound, results in the buildup of a metabolite called dihydrohonokiol-B (DHH-B), which is responsible for honokiol’s anxiolytic (anxiety-reducing) effects. DHH-B acts as a potent agent to reduce anxiety by targeting the GABA_A receptor-gated chloride channel complex in the brain, suggesting a specific mechanism through which DHH-B can alleviate anxiety.

Why this matters:

Magnolia bark and its extracts need to be administered repeatedly to achieve their effects, whereas DHH-B (dihydrohonokiol-B) provides immediate anxiety-reducing benefits. Unlike benzodiazepines, a common class of anxiolytics, DHH-B does not lead to motor dysfunction or dependency. This underlines DHH-B’s promise as a therapeutic option for anxiety disorders, showcasing its capacity to alter neurotransmitter systems for effective anxiolytic outcomes without the significant side effects associated with many traditional medications.

Clinical Studies

Honokiol, a putative anxiolytic agent extracted from magnolia bark, has no diazepam-like side effects in mice

Anxiety-reducing effects without affecting motor activity or muscle tone
Honokiol did not exhibit withdrawal symptoms seen with benzodiazepines
Honokiol did not disrupt learning, memory or central nervous system depression at anxiolytic doses

Synergy with Oxytocin, Sermorelin, GLP-1

DHH-B + Oxytocin

Oxytocin has been shown to decrease stress by its ability to reduce cortisol while DHH-B also has an anxiolytic effect by stimulating gaba receptors and manage stress and anxiety.

DHH-B + Sermorelin

DHH-B helps patients manage sleep patterns. Typcially used with Sermorelin which improves night time growth hormone secretion that has been shown to enhance deep sleep.

DHH-B + GLP-1

Cortisol has been shown to be anabolic to fat tissue and catabolic to muscle tissue putting effective weight loss on hold. The combination of GLP-1 with DHH-B has been used to mitigate stress-induced weight loss resistance.

References

Yuji Maruyama, Hisashi Kuribara, Eiko Kishi, Susan T Weintraub, Yoshihisa Ito, Confirmation of the anxiolytic-like effect of dihydrohonokiol following behavioural and biochemical assessments, Journal of Pharmacy and Pharmacology, Volume 53, Issue 5, May 2001, Pages 721–725, https://doi.org/10.1211/0022357011775848
Poivre M, Duez P. Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents. J Zhejiang Univ Sci B. 2017;18(3):194-214. doi:10.1631/jzus.B1600299
Mikhail Alexeev, Denise K. Grosenbaugh, David D. Mott, Janet L. Fisher, The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABAA receptors, Neuropharmacology, Volume 62, Issue 8, 2012, Pages 2507-2514, ISSN 0028-3908, https://doi.org/10.1016/j.neuropharm.2012.03.002.

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DHH-B

Cellular Pathways

Why this matters:

Clinical Studies

Synergy with Oxytocin, Sermorelin, GLP-1

References

a longevity science and wellness education network

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West Palm Beach, FL 33411

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DHH-B

Cellular Pathways

Why this matters:

Clinical Studies

Synergy with Oxytocin, Sermorelin, GLP-1

References

a longevity science and wellness education network

8144 Okeechobee Blvd Unit A West Palm Beach, FL 33411

Formulations

Providers

Learning

Support

Our Story

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8144 Okeechobee Blvd Unit A 
West Palm Beach, FL 33411