1-MNA

1-MNA, a novel myokine, is a game-changer in cellular health by blocking the enzyme NNMT and optimizing NAD levels in the cells. 1-MNA offers a comprehensive approach to cellular health. Its anti-inflammatory, anti-thrombotic properties and positive effect on vascular endothelium and skeletal muscle energy metabolism make it a promising supplement in the medical field.
Optimized NAD Levels: 1-MNA works to restore and optimize NAD levels in cells, a crucial component for cellular health and energy production.
Anti-inflammatory and Anti-thrombotic Properties: 1-MNA possesses anti-inflammatory and anti-thrombotic characteristics, contributing to improved vascular health.
Inhibition of NNMT: 1-MNA has been shown to inhibit the enzyme NNMT, which when present in high levels, is associated with various diseases. By inhibiting this enzyme, 1-MNA can contribute to overall cellular health and disease prevention.

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Cellular Pathways

1-MNA safely increases NAD levels and blocks NNMT, improves cell energy metabolism anti-inflammatory and anti-thrombotic properties positive effect on vascular endothelium

Why this matters:

SIRT-1 Downstream Effects

Stimulates caloric restriction and exercise pathways through these gene transcription factors:

Clinical Studies

NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism

NAD+/NADH and NADP+/NADPH redox systems are crucial for cellular redox balance and metabolism. Imbalances in these systems are linked to various diseases. Recent advances, including new biosynthetic enzymes and genetically encoded biosensors, have improved our understanding of how cells regulate NAD(H) and NADP(H) pools. Research is increasingly focused on redox stress and the role of NAD+-consuming proteins in maintaining cellular health.

Synergy with GLP-1s

Semaglutide, Tirzepatide, Liraglutide

Studies show 15% reduction in body weight when semaglutide was accompanied by caloric restriction and exercise. Using an exercise mimetic like LeuSynergy is foundational in weight loss and metabolic health outcomes.

Insulin Independent Pathways for Glucose Disposal

GLP-1

Increase in GLUT4 expression by activating AMPK

LeuSynergy

Increase in GLUT4 expression through SIRT1 deacetylation of PGC-1a

Improved Fat Oxidation

GLP-1

Direct effects on hepatocytes by activating genes involved in beta-oxidation of fatty acids

LeuSynergy

Activation of PGC-1a and PPAR resulting in an increase in fatty acid oxidation and oxidative phosphorylation

Oxidative Stress and Pancreatic Beta Cell Protection

GLP-1

Reduced oxidative stress in pancreatic islets. Increases B-cell mass by regulating cell kinectics and suppressing oxidative and ER stress, and amerlioration of glucolipotoxicity.

LeuSynergy

SIRT1 deacetylation and inhibition of NF-kB protecting beta cells from oxidative stress and inflammatory cytokines.

References

Xiao, Wusheng & Wang, Rui-Sheng & Handy, Diane &Loscalzo, Joseph. (2017). NAD(H) and DADP(H) Redox Couples and Cellular Endergy Metabolism. Antioxidants & Redox Signaling. 28. 10.1089/ars.

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1-MNA

Cellular Pathways

Why this matters:

SIRT-1 Downstream Effects

Clinical Studies

Synergy with GLP-1s

Semaglutide, Tirzepatide, Liraglutide

GLP-1

LeuSynergy

GLP-1

LeuSynergy

GLP-1

LeuSynergy

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a longevity science and wellness education network

8144 Okeechobee Blvd Unit A 
West Palm Beach, FL 33411

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1-MNA

Cellular Pathways

Why this matters:

SIRT-1 Downstream Effects

Clinical Studies

Synergy with GLP-1s

Semaglutide, Tirzepatide, Liraglutide

GLP-1

LeuSynergy

GLP-1

LeuSynergy

GLP-1

LeuSynergy

References

a longevity science and wellness education network

8144 Okeechobee Blvd Unit A West Palm Beach, FL 33411

Formulations

Providers

Learning

Support

Our Story

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8144 Okeechobee Blvd Unit A 
West Palm Beach, FL 33411