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AKG Product SUPPLEMENT FACTS

AKG+

AKG (Alpha-ketoglutarate) supplement enhances health and physical performance by being a crucial intermediate in the Krebs cycle, supporting cellular energy production. It aids in the synthesis of glutamine and other amino acids essential for muscle repair, growth, and recovery. AKG also promotes longevity by supporting cellular functions and reducing inflammation, thus maintaining muscle health.
Its role in energy metabolism makes it beneficial for improving metabolic health.

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Cellular Pathways 

AKG is formed from isocitrate through the action of the enzyme isocitrate dehydrogenase in a process that also results in the release of carbon dioxide. Once formed, AKG undergoes oxidative decarboxylation by the alpha- ketoglutarate dehydrogenase complex (α-KGDH), a process similar to the reaction catalyzed by the pyruvate dehydrogenase complex. This reaction converts AKG into succinyl-CoA, another compound in the Krebs cycle, and produces NADH from NAD+, which is later used in the electron transport chain to generate further ATP.
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Why this matters:

The role of AKG in the metabolic cycle is pivotal, acting as a critical control point that is responsive to the body’s energy demands and substrate availability. Many commercial AKG supplements are typically under-dosed, providing only 500mg, which is insufficient to harness the full benefits of AKG.
In contrast, AKG+ is formulated with a 3-gram dosage, ensuring an optimal level that is necessary to realize the comprehensive advantages of AKG supplementation.

Clinical Studies

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and mTOR
We show that α-KG inhibits ATP synthase and, similar to ATP synthase knockdown, inhibition by α-KG leads to reduced ATP content, decreased oxygen consumption, and increased autophagy in both C. elegans and mammalian cells. α-Ketoglutarate prevents skeletal muscle protein degradation and muscle atrophy.
Clinical Studies

Synergy with GLP-1, Sermorelin

AKG + Sermorelin Anti-Aging
The peptide-enhancing effects of AKG and sermorelin converge on similar pathways to improve muscle and cellular efficiency, particularly by enhancing protein synthesis and ATP production. Typically used in body composition and longevity protocols.
AKG enhances the effects of iCell™ on muscle performance through its impact on glutamine and protein synthesis, alongside energy production.
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References

  1. Zdzisińska B, Żurek A, Kandefer-Szerszeń M. Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity: Well-Known and Novel Possibilities of Therapeutic Use. Arch Immunol Ther Exp (Warsz). 2017 Feb;65(1):21-36. doi: 10.1007/s00005-016-0406-x. Epub 2016 Jun 20. PMID: 27326424; PMCID: PMC5274648.
  2. Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D. Alpha-Ketoglutarate: Physiological Functions and Applications. Biomol Ther (Seoul). 2016 Jan;24(1):1-8. doi: 10.4062/biomolther.2015.078. Epub 2016 Jan 1. PMID: 26759695; PMCID: PMC4703346.
  3. Cai X, Yuan Y, Liao Z, Xing K, Zhu C, Xu Y, Yu L, Wang L, Wang S, Zhu X, Gao P, Zhang Y, Jiang Q, Xu P, Shu G. α-Ketoglutarate prevents skeletal muscle protein degradation and muscle atrophy through PHD3/ADRB2 pathway. FASEB J. 2018 Jan;32(1):488-499. doi: 10.1096/fj.201700670R. Epub 2017 Sep 22. PMID: 28939592; PMCID: PMC6266637

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